SYNTHESIS, CHARACTERIZATION AND NEUROTOXIC EFFECT OF SCHIFF BASE LIGANDS AND THEIR COMPLEXES (Sintesis, Pencirian dan Pengaruh Nurotoksik Bes Schiff dan Kompleksnya)
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چکیده
Two ligands and eight complexes are successfully synthesized by reacting 1,8-diaminonapthelene with aldehyde/ketone derivatives in 1:2 ratio for ligand formation and 1:1 ratio for complex formations. The compounds are characterized through CHN elemental anaysis, IR spectroscopy, H NMR spectroscopy, melting point and magnetic susceptibility determination. The neurotoxicity of compounds is evaluated using neuroblastoma SH-SY5Y cell lines and it was indicate the cells were non-toxic either for ligands and complexes after 24 hours exposure.
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تاریخ انتشار 2011